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Chemotherapy for Advanced Prostate Cancer

Chemotherapy is the delivery of powerful drugs intravenously, orally, or in combination, to kill cancer cells. Chemotherapy is not used as an initial treatment because chemotherapy drugs are not as effective as hormone therapy. However, after hormone therapy becomes less effective, various chemotherapy drugs may improve symptoms, reduce PSA levels, and/or decrease prostate cancer cells.

  • Docetaxel injection is used alone or in combination with other medications to treat certain types of breast, lung, prostate, stomach and head and neck cancers. Taxotere injection is in a class of medications called taxanes. It works by stopping the growth and spread of cancer cells. Approved by the FDA in 2004, Docetaxel was the first treatment proven to prolong survival in castrate-resistant prostate cancer patients.
  • Cabazitaxel (Jevtana®) is a prescription anti-cancer medicine used with the steroid medicine prednisone. It is used to treat men with advanced prostate cancer that has worsened (progressed) after treatment with other anti-cancer medicines, including docetaxel. This means Jevtana may be an option for patients if docetaxel is no longer working.
  • Mitoxantrone is used to treat leukemia and prostate cancer, as well as other conditions. Mitoxantrone is part of a general group of chemotherapy drugs known as antibiotics. It stops the growth of cancer cells, which are then destroyed. The combination of mitoxantrone and prednisone is approved as a second-line treatment for metastatic castrate-resistant prostate cancer.

Treatment Options for Advanced Prostate Cancer

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